White, Round IP 203 Pill is an combination of Acetaminophen 325 mg and Oxycodone Hydrochloride 5 mg. It is a strong painkiller used in the treatment of chronic pain.

IP 203 Pill is only available on prescription, Initial recommended doses of white round pill ip 203 is single pill once a day.

White pill ip 203 is intended to be taken the whole and must not be broken, chewed, crushed, or dissolved in liquid. 

IP 203 Pill Key Facts

It is an extended release pill, Which acts for 24 hour and hence, a single dose of ip 203 pill is recommended dose of this pill.

ip 203 pill works by blocking pain signals from reaching to brain.

You might get addicted by long term use of ip 203 pill, Follow your doctor’s advice to such side effects.

Constipation is the most common side of white pill ip 203, Your doctor might prescribe you Naloxone to get rid of constipation.

Common dosage of white round pill ip 203 is said to be single dose in the evening.

IP 203 Pill Mechanism of Action

Acetaminophen – pill ip 203 works by blocking production of prostaglandins. They are required to build pain signals to the brain.

Oxycodone – It works by inhibiting ascending pain pathways, altering the perception of and response to pain. It produces generalised CNS depression.

Uses of IP 203 Pill

ip 203 pill is a strong opiate painkiller used in the treatment of chronic pain like post operative pain, cancerous pain, surgical pain, trauma.

1.Post-operative pain

It is an mild to moderate pain which generally occurs after surgical procedure. pill ip 203 is usually given in serious conditions only.

According to this study, Single dose of Oxycodone (pill ip 203) is sufficient to manage most type of post operative pain. this pill is also considered more stronger than codein pill also.

Double dose of ip 203 pill provides good analgesia to half of those treated, comparable to commonly used non‐steroidal anti‐inflammatory drugs, with the benefit of longer duration of action.oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults

2.Low Back Pain

it is the pain which occurs in the area of below the ribcage. It is more common type of pain in united states.

Study conducted to test the effectiveness of Acetaminophen + Oxycodone combination reveals that the combination is very effective in low back pain.

3.Rheumatic Arthritis

Pain of rheumatic arthritis is growing concern in united states & most of the people are not getting strong pain killers which are required to cure their pain.

This study suggest, Oxycodone/acetaminophen at low dosages for the treatment of chronic pain in RA patients can be a good alternative to non-steroidal antiinflammatory drugs (NSAIDs).

Side effects of ip 203 pill

Like any other medications, ip 203 pill also cause some mild to moderate side effects. Most of these side effects does not require any special attention and goes away on their own.

• Nausea,
• Constipation,
• Headache,
• Pruritus,
• Insomnia,
• Dizziness,
• Abdominal pain,
• Chills and Fever,
• Diarrhoea,
• Dyspepsia,
• Nervousness,
• Tremor,
• Cough,
• Rash.

Contraindications & Precautions

• Allergic Reactions: Patients with past history of allergic reactions to any of the ingredient of pill ip 203 should avoid this pill completely.

• Disease Conditions – Patients with chronic bronchial asthma, hypercarbia, chronic constipation, COPD, cor pulmonale, Seizures should take this pill with precautions.
• Kidney & Liver Disease – Lower doses are advised in renal and hepatic impairment.
• Alcohol – Consumption of any alcoholic beverages should be avoided while taking ip 203 pill.
• Driving – white pill ip 203 may make you feel dizzy and sleepy, in such conditions it is best not to drive or operate any heavy vehicle.
• Pregnancy – white pill ip 203 is pregnancy category c pill which needs to be avoided while being pregnant.

Drug Interaction of ip 203 pill

Drug interaction can change the way ip 203 pill works and may exhibit some undesired adverse interactions which might be harmful to the consumer.

• Ketoconazole, Erythromycin – may inhibit the metabolism of oxycodone.
• Diazepam,
• Alprazolam,
• Lorazepam,
• Xanax,
• Butorphanol,
• Nalbuphine,
• Pentazocine,
• Cetirizine,
• Diphenhydramine.

Storage of ip 203 pill

• Store ip 203 pill in a cool and dry place and protected from moisture.
• Keep it out of the reach of children.

In case of expired ip 203 pill, Talk to your pharmacist about recycling of a product or safe disposal of pill.

Frequently Asked Questions

Orange Round Pill with I 2 marking impression is an antidepressant pill containing Amitriptyline Hydrochloride 25 mg as an active ingredient.

Amitriptyline Hydrochloride 25 mg (Orange Round I 2 Pill) is used in the treatment of Depression, Anxiety, Nocturnal enuresis, Prophylaxis of migraine and Neuropathic pain.

I 2 Orange Round Pill does not comes under Controlled Substances Act (CSA) and hence you can get it on normal prescription without any restriction like narcotic substances.

• Always take I 2 Orange Round Pill at the bed time as it may make you feel very sleepy or dizzy.
• I 2 Orange Round Pill may cause some withdrawal symptoms if discontinued suddenly. Talk to your doctor about discontinuation plan.
• This pill may be prescribed for a longer duration, should be used according to doctor’s recommendation.
• Common dosage of I 2 Orange Round Pill is said to be single dose in the evening.

I 2 Pill Uses

I 2 Pill is clinically proven to show significant improvement in the treatment of Depression, Nocturnal enuresis, Prophylaxis of migraine & Neuropathic pain.

1.Depression

It is an mental health condition characterized by the significant decrease in mood, loss of interest in doing daily interest & causing significant defacement in daily life.

I 2 Pill (Amitriptyline) is FDA approved medication to treat depression in adults.

According to this study, Amitriptyline (I 2 Pill) is an significantly effective drug in the treatment of Depression. However, the study also shows that Amitriptyline is also associated with common side effects like Headache & Diziness which will be discussed in details in the side effect section. (Source)

2.Nocturnal enuresis

It is also known as nighttime incontinence or nocturnal enuresis, It is a condition characterized by the urination while asleep after the age (5 Years) at which staying dry at night can be reasonably expected.

In this study conducted on 50 enuretic childrens aged between 5-15, It was found that Amitriptyline (I 2 Round Pill) in doses of 25 mg decreased frequency of nights with enuresis. (Source)

Another comparative study shows superiority of Amitriptyline over Desmopressin. Also, 25 mg of Amitriptyline has lesser side effects compared to drug Desmopressin. (Source)

3.Neuropathic Pain

Neuropathic Pain is a result of damaged nervous system, a shooting, stabbing or burning sensation are common types of neuropathic pain. they can be temporary or sometimes last longer than usual duration.

Amitriptyline (I 2 Pill) is recommended as a first line treatment on Neuropathic pain. It does significantly reduces the neuropathic pain by reducing body’s response to the pain. (Source)

This recent study conclude that Amitriptyline (I 2 Pill) relieves pain in diabetic neuropathy and this effect is independent of mood elevation. (Source)

How does I 2 Orange Round Pill work?

I2 (Amitriptyline Hydrochloride 25 mg) Pill is a popular and clinically proven antidepressant. It works by inhibiting the neuronal reuptake of serotonin (5-HT) and/or norepinephrine by the presynaptic neuronal membrane, hence increasing the synaptic concentration in the CNS.

It also possesses affinity for muscarinic and histamine (H1) receptors to varying degrees.

Adverse Effects / Side Effects

Like any other medications, I 2 Orange Pill also cause some mild to moderate side effects.

The most commonly encountered side effects of I 2 Orange Pill include:

• Weight gain,
• Constipation,
• Xerostomia,
• Dizziness,
• Headache,
• Somnolence,

Severe Side Effects

• CNS depression,
• Bone fractures,
• Bone marrow suppression,
• Heart block,
• Arrythmias,
• Tachycardia,
• Palpitation,

Do not get frightened by the severe side effects, They are very rare and most of the users don’t even get it.

Common side effects usually goes away on its own without any special treatment.

Contraindications & Precautions

Contraindications and Precautions should be considered as most critical aspects while taking a drug or a pill. The following are significant considerations for I 2 Pill:

• Allergic Reactions: Patients with past history of allergic reactions to any of the ingredient of I 2 Pill should avoid this pill completely.
• I 2 Pill should not be used if there is a history of Heart diseases like Arrhythmias, recent Myocardial infarction, or Heart failure. (As per the FDA product labeling. Amitriptyline toxicity may cause acute myocardial infarction)
• Disease Conditions – Patients with Angle-closure glaucoma, Urinary retention, Seizures should take this pill with precautions.
• Kidney & Liver Disease – Lower doses are advised in renal and hepatic impairment.
• Discontinue I 2 Pill before undergoing any surgical procedure as it may interact with anesthetic agents and cause severe complications in surgical procedure.
• Alcohol – Consumption of any alcoholic beverage should be avoided while taking I 2 Pill as it may cause severe side efffects.

Drug Interactions of I 2 Pill

Drug interaction can change the way i2 pill works and may produce some undesired adverse interactions.

It is advised to avoid any other medication along with i2 pill which are listed below.

• Astemizole,
• Cisapride,
• Disopyramide,
• Ibutilide,
• Indapamide,
• Pentamidine,
• Pimozide,
• Procainamide,
• Quinidine,
• Sotalol,
• Terfenadine,

Adrenaline, Phenylephrine – May potentiate CV effects of sympathomimetic agents.

Betanidine, Clonidine – May reduce antihypertensive effects of adrenergic neuron blockers.

Quinidine, Amiodarone – May increase ventricular arrythmias with antiarrhythmics.

Fluconazole – May increase serum concentrations.

Cimetidine – Increased plasma concentration.

Storage of I2 Pill

• Store i2 Pill in a cool and dry place and protected from moisture.
• Keep it out of the reach of children.

In case of expired i2 pill, Talk to your pharmacist about recycling of a product or safe disposal of pill.

Frequently Asked Questions