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Tramadol Hydrochloride – Uses, Dosage, Side Effects

tramadol hydrochloride

Tramadol is a narcotic analgesic used in the treatment of severe to moderate pain.Tramadol is a narcotic analgesic used in the treatment of severe to moderate pain.

The extended-release-tablet formulation is used to treat chronic pain when normal painkillers no longer work.

Tramadol may cause addiction if not used under supervision of a doctor. Special care must be taken while taking Tramadol Hydrochloride.

Drug categoryNarcotic Analgesics
Type of formulationsTablet, Syrup, Capsule & Liquid drops
AvailabilityOnly on prescription
Pregnancy categoryC
ATC ClassificationN02AX02 
Common brand namesInvodol, Larapam, Mabron, Maneo, Marol, Maxitram, Oldaram, Tilodol, Tradorec, Tramquel, Tramulief, Zamadol, Zeridame and Zydol

Key Facts of Tramadol Hydrochloride

Strong painkiller used only when normal painkillers does not provide significant relief.

Due to its opioid properties it causes most common side effects like headache and dizziness.

It is not advised to drive a vehicle or operate any vehicle after taking Tramadol.

Make sure that you do not consume more dose of Tramadol than the prescribed dose.

It is super necessary to avoid alcohol while taking Tramadol as it may make you more prone to serious side effects.

Types of Tramadol Hydrochloride

Immediate release tablets – they are mainly used for rapid onset of action, usually contains 50 mg of Tramadol Hydrochloride.

Extended release tablets – this type of formulation is mainly used for the management of chronic pain for longer duration. it may contain 50mg, 75mg, 100mg, 150mg, 200mg, 300mg or 400mg of tramadol.

Liquid drops – those people who find difficult to swallow a pill can go with this type of preparation. these drops can contain 100mg of tramadol in 1ml of liquid.

Injection – it is a rapid acting formulation, primarily used in the hospitals in emergency conditions.

Dissolve in the mouth tablet – this type of tablets gets easily dissolved in the mouth.

How Does Tramadol Works?

Tramadol works on the CNS by inhibiting reuptake of norepinephrine, serotonin and enhances serotonin release. Tramadol alters perception and response to pain by binding to mu-opiate receptors in the CNS.

Half-lifeSix hours
Time to reach peak plasma concentrationExtended Release: 12 hours, Immediate Release: 1.6 to 1.9 hours
StrengthExtended Release: 100 mg, 200 mg, 300 mg, Immediate Release: 50 mg
ExcretionExcreted mainly in urine

Precautions Of Tramadol Hydrochloride

Tramadol Hydrochloride is not suitable for some people. Take precautions if you have any of the following conditions.

  • Allergic to Tramadol or any other ingredient of the pill.
  • Kidney or Liver problems.
  • If you are suffering from emotional disturbance or depression.
  • If you have a history of epilepsy, seizure or head injury.
  • Addiction of alcohol or strong painkiller.
  • Pregnant or breastfeeding women’s should avoid this medication.

Side Effects of Tramadol Hydrochloride

Although, Tramadol Hydrochloride is a safe medication but in some patient, it can cause some side effects.

Most of the side effects occur during the initial treatment rather than maintenance doses of the drug.

Common side effects







Serious side effects

Serious side effects are very rare and may occur in a very small percentage of patient consuming tramadol.

Respiratory depression,





If any side effects bother you and do not go away in a short time, you should immediately contact the doctor or medical health professional.

Drug Interaction of Tramadol Hydrochloride

Serotonin-norepinephrine reuptake Inhibitor – Subsequent consumption of Tramadol Increases the risk of convulsions or serotonin syndrome.

Bupropion, Mirtazapine, Tetrahydrocannabinol – Increases the risk of convulsions.

Carbamazepine – Decreases serum concentrations of Tramadol Hydrochloride.

Other drugs which should be avoided:

  • Furazolidone
  • Iproniazid
  • Isocarboxazid
  • Linezolid
  • Methylene Blue
  • Moclobemide
  • Nalmefene
  • Naltrexone
  • Nialamide
  • Phenelzine
  • Procarbazine
  • Rasagiline
  • Safinamide
  • Samidorphan
  • Selegiline
  • Tranylcypromine

Safety of Tramadol Hydrochloride In Pregnancy

Tramadol is pregnancy category c drug and not completely safe to take while being pregnant.

Using Tramadol during pregnancy can cause neonatal withdrawal syndrome or birth defects in the newborn baby.

It is advised to inform your doctor right away if you think you are pregnant or if you plan to become pregnant while using this medicine.

Tramadol Safety In Breastfeeding

Usually, it is safe to breastfeed while taking tramadol medication. As it passes into breast milk in very small quantity but it’s unlikely to harm your baby.

However, Contact your doctor if you feel any notable changes or side effects in your baby.

Common Questions Regarding Tramadol Hydrochloride

  1. What is tramadol hydrochloride?

    Tramadol is a narcotic analgesic drug, used in the management of chronic pain like postoperative pain & other long term pain disease.

  2. What are common side effects of tramadol hydrochloride?

    The most common side effects of tramadol are nausea, dizziness, constipation, vomiting, somnolence, and headache.

  3. What is the common dosage of tramadol 50 mg medication?

    The usual dosage is decided by your doctor depending on your condition and response to treatment. The usual dose is once a day and may vary according to your condition.

  4. How long should i consume tramadol medication?

    Do not consume tramadol for more than 10 days unless it is recommended by your doctor.

  5. What if i dont get relief after consuming tramadol?

    Talk to your doctor if you do not feel any relief after taking tramadol. ask your doctor for alternative drug.

  6. Is tramadol hydrochloride addicted in nature?

    Yes, Tramadol is narcotic analgesic and it can cause addiction if misused.

  7. Can i drink alcohol while taking tramadol?

    No, do not drink alcohol while taking tramadol as it may increase the risk of side effect.

  8. Can I drive the vehicle after taking tramadol hydrochloride?

    Do not drive a car or operate a heavy machinery if tramadol makes you sleepy during the daytime, gives you blurred vision or makes you feel dizzy, sleepy or unable to concentrate or make decisions. 

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