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E612 Pill – Uses, Dosage, Side Effects & Precautions

E612 5 Pill

What is Opana E612 5 Pill?

What is Opana E612 5 Pill?
What is Opana E612 5 Pill?

Opana E612 5 is a prescription medication used to treat moderate to severe pain. It belongs to the opioid class and contains 5 mg of oxymorphone.

The pill is round, blue, and imprinted with “E612 5.” Due to its potency, it’s a Schedule 2 controlled substance.

Pregnant individuals should consult their healthcare provider before use (Category C). The pill is supplied by Endo Pharmaceuticals Inc., but repackagers like Lake Erie Medical and Surgical Supply may also distribute it.

  • Name: E612 5 Pill
  • Generic Name: Oxymorphone
  • Brand: Opana
  • Appearance: The E612 5 pill is easily recognizable with its distinct round shape, blue color, and an imprint of “E612 5.” Measuring 9mm, it is a compact medication.
  • Strength: Each pill contains 5 mg of oxymorphone, a potent opioid used for pain management.
  • Usage: Prescribed for the treatment of moderate to severe pain, E612 5 belongs to the narcotic analgesics class, acting on the central nervous system.
  • Controlled Substance: Classified as a Schedule 2 controlled substance under the Controlled Substance Act (CSA), indicating its high potential for abuse.
  • Pregnancy Category: Categorized as Category C, caution is advised during pregnancy, and consultation with a healthcare provider is recommended to weigh potential risks.
  • Manufacturer: Supplied by Endo Pharmaceuticals Inc., ensuring quality and adherence to pharmaceutical standards.

Uses of E612 5 Pill (Opana):

  1. Pain Relief: E612 5 Pill, with oxymorphone, is used to ease moderate to severe pain.
  2. For Surgery Recovery: Doctors may prescribe it to help manage pain after surgeries.
  3. Chronic Pain: It’s an option for ongoing pain when other treatments aren’t enough.
  4. Cancer Pain: Sometimes used for people with pain related to cancer.
  5. Palliative Care: Given to improve the comfort of those with serious illnesses.
  6. Short-Term Use: Usually recommended for a short period to reduce the risk of dependence.
  7. Personalized Treatment: Doctors may suggest it based on an individual’s pain and health situation.
  8. Pregnancy Caution: If needed during pregnancy, it’s used cautiously under a doctor’s guidance.
  9. Prescription-Only: You can only get E612 5 with a prescription from a doctor.

For safe use, always follow your doctor’s advice, share your medical history, and take it only as prescribed.

How to take it?

When taking E612 5 Pill (Opana), it’s crucial to follow your doctor’s instructions closely. Ensure you take the prescribed dosage as directed, swallowing the pill whole with water, either with or without food.

Aim for a consistent daily schedule to maintain steady levels in your system. If you happen to miss a dose, take it as soon as you remember, but skip it if your next dose is approaching.

Possible Side Effects of E612 5 Pill (Opana):

E612 5 (Opana) may cause side effects, including drowsiness, constipation, nausea, headache, sweating, itching, changes in mood, and, rarely, difficulty breathing or allergic reactions. To mitigate these effects:

  1. Drowsiness/Dizziness: Avoid activities requiring alertness initially.
  2. Constipation: Stay hydrated and include fiber in your diet.
  3. Nausea/Vomiting: Take the pill with food.
  4. Headache: Consult your healthcare provider if severe.
  5. Sweating: Stay hydrated and maintain a comfortable environment.
  6. Itching/Rash: Report persistent symptoms to your healthcare provider.
  7. Difficulty Breathing: Seek immediate medical attention.
  8. Changes in Mood: Consult your healthcare provider about significant mood changes.
  9. Allergic Reactions: Seek emergency medical help for severe reactions.

Individual responses vary; promptly inform your healthcare provider about any concerns.

Precautions and Warnings for E612 5 Pill (Opana):

  1. Prescription Only: Only use E612 5 with a doctor’s prescription.
  2. Individual Response: People react differently; report any unusual side effects to your doctor.
  3. Dependence and Abuse: Follow your doctor’s instructions to minimize the risk of dependence and abuse.
  4. Pregnancy and Breastfeeding: Tell your doctor if you’re pregnant, planning to be, or breastfeeding.
  5. Driving and Machinery: Be cautious, as E612 5 may cause drowsiness. Avoid driving or operating machinery if affected.
  6. Alcohol Interaction: Don’t drink alcohol while on E612 5 to avoid intensified side effects.
  7. Medical History: Share your medical history, especially if you’ve had substance abuse, mental health issues, or respiratory conditions.
  8. Other Medications: Inform your doctor about all medications, including over-the-counter drugs and supplements.
  9. Withdrawal Risk: Don’t stop E612 5 suddenly; consult your doctor before discontinuing.
  10. Allergies: If you’re allergic to opioids or any pill components, let your doctor know.
  11. Emergency Situations: Recognize signs of severe reactions and seek immediate medical help.

Stay in touch with your doctor, follow instructions carefully, and speak up about any concerns during your E612 5 treatment.

Drug Interactions with E612 5 Pill (Opana):

E612 5 (Opana) may interact with other medications, potentially affecting its effectiveness or causing side effects. Inform your healthcare provider about all medications you are taking, including:

  1. Other Opioids: Concurrent use with other opioids may increase the risk of respiratory depression and other side effects.
  2. Sedatives and Hypnotics: Combining E612 5 with sedatives or sleep medications can enhance drowsiness and respiratory depression.
  3. Muscle Relaxants: Interaction with muscle relaxants may intensify sedation and dizziness.
  4. Benzodiazepines: Combining E612 5 with benzodiazepines can lead to respiratory depression and increased sedation.
  5. Monoamine Oxidase Inhibitors (MAOIs): Using E612 5 with MAOIs may result in severe reactions. MAOIs are often used to treat depression.
  6. Antidepressants: Some antidepressants may interact with E612 5, potentially leading to serotonin syndrome.
  7. Antipsychotics: Combining E612 5 with antipsychotic medications may increase the risk of sedation and respiratory depression.
  8. Antihistamines: Interaction with antihistamines can intensify drowsiness.
  9. Diuretics: Diuretics may lead to low blood pressure when used concurrently with E612 5.
  10. CYP3A4 Inhibitors: Medications that inhibit the CYP3A4 enzyme may affect the metabolism of E612 5, potentially altering its effects.

This list is not exhaustive, and it’s crucial to provide your healthcare provider with a complete list of all medications, including over-the-counter drugs and supplements, to ensure safe use of E612 5 and minimize the risk of interactions.

Safety in Pregnancy & Breastfeeding


  • Category C: E612 5 is classified as Pregnancy Category C, indicating caution. Discuss potential risks and benefits with your healthcare provider before use.
  • Consultation: If pregnant or planning pregnancy, inform your healthcare provider promptly to assess the most suitable course of action.
  • Risk Evaluation: The potential benefits to the mother must be carefully weighed against potential risks to the fetus.


  • Caution Advised: E612 5 may pass into breast milk, and its safety during breastfeeding is not well-established.
  • Consultation Needed: Discuss breastfeeding considerations with your healthcare provider to make an informed decision.
  • Potential Effects on the Infant: Consider potential effects on the nursing infant, including sedation and respiratory depression.

Frequently Asked Questions

  1. What is E612 5 used for?

    E612 5 is prescribed to manage moderate to severe pain.

  2. How does it work?

    It belongs to a group of medicines called opioids, which act on the central nervous system to alleviate pain.

  3. Can I take it without a prescription?

    No, E612 5 is available only with a doctor’s prescription.

  4. What are the common side effects?

    Common side effects may include drowsiness, constipation, nausea, and headache.

  5. Can I drink alcohol while taking E612 5?

    It’s recommended to avoid alcohol as it can intensify side effects.

  6. How should I take it?

    Take the prescribed dosage with water, with or without food, and avoid crushing or breaking the pill.

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