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Drugs

Paracetamol – Uses, Dosage, Precautions & Warnings

Paracetamol is an anti-inflammatory, analgesic & antipyretic drug used in the treatment of Fever, Moderate Pain, Post-immunisation pyrexia and Bodyache.

paracetamol

Paracetamol is an anti-inflammatory, analgesic & antipyretic drug used in the treatment of Fever, Moderate Pain, Post-immunisation pyrexia and Bodyache.

Paracetamol is also known by the name of Acetaminophen, It is also a choice of drug for treating pain in the pregnant women’s.

Category of drugNSAID’s
UsesFever, Moderate Pain, Post-immunisation pyrexia and Bodyache & Dysmenorrhea
Side EffectsAcidity, Peptic Ulcer, Nausea, Vomiting, Constipation, Insomnia, Pruritus, Stevens-Johnson syndrome.
Strength325, 500 and 1000 mg.

Read – Watson 853 Pill – Identification, Uses & Dosage

Key Facts of Paracetamol

Paracetamol can be combined with other anti sickness medicines and it is one of the most common ingredient of cold and flu medicines.

Always consume Paracetamol after a meal to avoid gastric side effects like acidity and constipation.

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It is safe to consume Paracetamol in pregnancy and breastfeeding.

Maximum dosage of Paracetamol is 4 grams a day (in serious conditions only).

Popular Brand Names – Alvedon, Calpol, Disprol, Hedex, Mandanol, Medinol, Panadol.

Dosage of Paracetamol

Dosage and strength of paracetamol will be decided by your doctor and it will be decided by your condition and response to treatment.

Usual dose of paracetamol in fever is 500 mg of paracetamol every 8 – 12 hours. For Moderate to mild pain 325 mg along with any muscle relaxant is sufficient.

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For Post-immunisation pyrexia and Bodyache, the usual dose is 500 mg of paracetamol once a day.

Ask your doctor or pharmacist for dosage of paracetamol in any other conditions.

Read – White 44175 Pill – Uses, Dosage, Side Effects

Precautions of Paracetamol

Do not consume alcohol while taking paracetamol, as it may make your symptoms more worst.

Patient with known allergic to paracetamol should avoid this and demand for other alternate medicine.

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Special precaution should be taken in the patients with kidney or liver failure.

Inform your doctor and pharmacist about any other drugs you are taking.

Never take more than the recommended dose by prescriber or pharmacist. Taking too much paracetamol can cause damage to your liver.

Side Effects of Paracetamol

Like all other medicines, Paracetamol also causes some mild to severe side effects. Although they are very rare and happens in about 1-5% of patients taking it.

Following is the list of common side effects of paracetamol:

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  1. Nausea and Vomiting
  2. Vertigo
  3. Acidity
  4. Gastric Ulcers
  5. Constipation
  6. Insomnia
  7. Flushing
  8. Pruritus
  9. Stevens-Johnson syndrome 

Drug Interaction of Paracetamol

Drug interaction can change the way paracetamol works and may alter the way it works. Drug interactions can cause some serious side effects.

Following is the list of drugs which interact with paracetamol:

  • Phenytoin,
  • Phenobarbital,
  • Carbamazepine,
  • Primidone,
  • Warfarin,
  • Metoclopramide,
  • Domperidone,
  • Probenecid,
  • Chloramphenicol.

Read – 44334 Pill – (Oval-Oblong shaped pill)

How does it works?

Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS. 

How to store paracetamol tablet?

It is recommended to store paracetamol in airtight container which comes with it. Keep it away from direct sunlight and moisture.

Keep it out of reach from children’s and pets.

Read – T 192 Pill – Identification, Uses, Precautions & Side Effects

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FAQs of Paracetamol

  1. What is paracetamol tablet?

    Paracetamol is an analgesic, anti-inflammatory medicine which is used in the treatment of Fever, Moderate Pain, Post-immunisation pyrexia and Bodyache.

  2. What are common side effects of paracetamol tablet?

    Common side effects of paracetamol are Nausea, Vomiting, Constipation, Acidity, Headache, Insomnia, Pruritus and Skin allergies.

  3. Can i take paracetamol tablets for longer duration?

    No, it is not recommended to take paracetamol for longer duration than 10 days. unless it is recommended by the doctir.

  4. Can i drink alcohol while taking Paracetamol?

    No, it is not recommended to drink alcohol while taking paracetamol as it will make you more dizzy or

  5. Can i drive vehicle after taking paracetamol?

    If paracetamol makes you feel dizzy or sleepy then you should avoid driving a vehicle or operate any heavy machinery.

  6. Does paracetamol affect my fertility?

    No, there are no evidence of paracetamol affecting fertility of either in mens or womens.

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Drugs

Ibuprofen: Uses, Dosage, Precautions & Warnings

Ibuprofen is a Non-Steroidal Anti Inflammatory drug used in the treatment and management of pain and inflammation.

Ibuprofen: Uses, Dosage, Precautions & Warnings

Ibuprofen is a Non-Steroidal Anti Inflammatory drug used in the treatment and management of pain and inflammation.

It acts by inhibiting COX enzymes in the body which are responsible for the production of prostaglandins which are required for the pain and inflammation response.

Uses of ibuprofen

Headache

Backache

Stomach Pain

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Toothache

Post Operative Pain

Dysmenorrhea

Arthritis

Gout

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Fever

Dosage of ibuprofen

Mild to moderate pain200-400 mg 4-6 hourly
Dysmenorrhea200-400 mg 4-6 hourly
Osteoarthritis400-800 mg 3-4 times daily
FeverInitially, 400 mg then, 400 mg 4-6 hourly or 100-200 mg 4 hourly
Gout 200-400 mg 4-6 hourly
Dosage of ibuprofen

Side effects of ibuprofen

Like all the medications, Ibuprofen also causes some mild to severe side effects.

Common side effects of ibuprofen include:

If any of these side effects bother you in the daily activities, then you should immediately contact your nearby doctor.

Precautions and warnings related to ibuprofen

Avoid consumption of alcohol while taking ibuprofen.

Do not consume ibuprofen for more than 10 days.

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If you do not feel any relief after taking ibuprofen, Kindly report to your doctor or pharmacist.

Always consume ibuprofen after a meal to avoid any serious side effects.

Discontinue the use of ibuprofen if you feel any allergic response after taking ibuprofen.

Drug Interactions

Following is the list of drugs which are said to have interaction with ibuprofen.

  • lithium
  • Warfarin
  • Oral hypoglycemics
  • Methotrexate medication
  • Angiotensin-converting enzyme inhibitors
  • Beta-blockers
  • Diuretic
  • Paracetamol

Avoid taking any other medicines along with ibuprofen, Also inform your doctor about your current nutritional supplements.

How does ibuprofen works?

Ibuprofen works by inhibiting COX enzymes in the body, Which are required by the body to produce pain and inflammatory receptors prostaglandins.

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How to store ibuprofen medications?

Always store ibuprofen medication in airtight container, away from light and moisture.

It recommended to keep medications away from childrens and pets as well.

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Drugs

Naproxen: Uses, Dosage, Side Effects & Warnings

Naproxen is a non steroidal anti-inflammatory drug, which is used in the management of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhoea, acute musculoskeletal disorders and acute gout.

naproxen

Naproxen is a non steroidal anti-inflammatory drug, which is used in the management of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhoea, acute musculoskeletal disorders and acute gout.

Drug ClassNSAIDs
Usesrheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhoea, acute musculoskeletal disorders and acute gout.
Available Strengths250, 500,1000 mg
Pregnancy CategoryC

Key Facts of Naproxen

It is recommended to take naproxen drug after a meal to avoid severe side effects of naproxen.

Do not use naproxen for longer duration to avoid addiction of naproxen.

Avoid alcohol while using naproxen as it will make you more dizzy and sleepy.

Confusion, headache, ringing in the ears, changes in vision are more common side effects of naproxen.

Your doctor will also give you antacid to avoid stomach ulcers.

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Dosage of Naproxen

Dosage of naproxen can vary according to your conditions. Your doctor will decide your dose according to your conditions and treatment response.

The usual dose of naproxen is 500 mg tablet twice a day, with a maximum dose of 1000 mg per day.

Side effects of Naproxen

Like all other medicines naproxen also causes some side effects. Although they are very rare and may happen’s in 10% of people taking it.

Common side effects of naproxen are as follows:

  • confusion
  • headaches
  • ringing in the ears
  • changes in vision
  • tiredness and feeling sleepy
  • dizziness
  • rashes

Contact your doctor or nearby if any of these side effects bother in your life.

Serious side effects can also happen with naproxen and they are as follows:

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  • Gastrointestinal obstruction,
  • Inflammation,
  • Bleeding,
  • Ulceration,
  • Stroke,
  • Anaphylactic reactions.

Seek emergency help if any of these serious side effects happens to you.

Drug Interaction of Naproxen

Drug interaction can change the way your drug works and may produce some undesired effects.

Following is the list of drugs which may interact with naproxen and should be avoided while taking naproxen.

  • Ibuprofen
  • Naproxen
  • Diclofenac
  • Celecoxib
  • Mefenamic acid
  • Etoricoxib
  • Iindomethacin
  • Paracetamol
  • Ramipril 
  • Quinapril 
  • Enalapril 
  • Lisinopril 

Before consuming naproxen, talk to your doctor about your ongoing medicines to know any possible drug interaction.

Mechanism of Action of Naproxen

Naproxen reversibly inhibits the COX-1 and COX-2 enzymes which leads to decreased level of prostaglandins which are responsible for pain and inflammation sensation.

Duration Of Action<12 hours.
Onset Of Action30-60 minutes.
AbsorptionReadily absorbed from the gastrointestinal tract.
MetabolismExtensively metabolized in the liver by CYP1A2 and CYP2C9 isoenzymes
ExcretionMainly via urine (approx 95%) as unchanged drug and metabolites

How to Store Naproxen

Naproxen should be stored in the airtight container and away from the light and moisture. Also keep it away from the pets & children’s.

Ask your pharmacists about recycle program and about disposal of expired medicine.

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FAQs of Naproxen

  1. What is the naproxen drug?

    Naproxen is a non steroidal anti-inflammatory drug, which is used in the management of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhoea, acute musculoskeletal disorders and acute gout.

  2. How does naproxen works?

    Naproxen reversibly inhibits the COX-1 and COX-2 enzymes which leads to decreased level of prostaglandins which are responsible for pain and inflammation sensation.

  3. Can i take naproxen tablet for longer duration?

    Do not take naproxen tablet for more than 10 days, unless it is recommended by the doctor.

  4. What are common side effects of naproxen tablet?

    Confusion, headaches, ringing in the ears, changes in vision, tiredness and feeling sleepy, dizziness, rashes are common side effects of naproxen tablet.

  5. Is naproxen addictive in nature?

    No, naproxen is not considered as an active ingredient, but it should be consumed with care.

  6. Does naproxen cause stomach ulcers?

    Yes, like all other NSAIDs naproxen also causes stomach ulcers due to excessive secretion of acid in stomach.

  7. Can i drink alcohol while taking naproxen?

    No,it is not recommended to drink alcohol while taking naproxen medication.

  8. Is it safe to use naproxen in pregnancy and breastfeeding?

    Naproxen is pregnancy category c drug and cause potentially fatal effects on unborn child.

  9. Can i drive a vehicle after taking naproxen?

    If naproxen make you dizzy or sleepy then you should avoid driving vehicle or operating any heavy machinery which requires concentration.

  10. Will naproxen affect my fertility?

    No, there is no such incidence of naproxen affecting fertility in males or females.

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Drugs

Tramadol Hydrochloride – Uses, Dosage, Side Effects

Tramadol is a narcotic analgesic used in the treatment of severe to moderate pain.Tramadol is a narcotic analgesic used in the treatment of severe to moderate pain.

tramadol hydrochloride

Tramadol is a narcotic analgesic used in the treatment of severe to moderate pain.Tramadol is a narcotic analgesic used in the treatment of severe to moderate pain.

The extended-release-tablet formulation is used to treat chronic pain when normal painkillers no longer work.

Tramadol may cause addiction if not used under supervision of a doctor. Special care must be taken while taking Tramadol Hydrochloride.

Drug categoryNarcotic Analgesics
Type of formulationsTablet, Syrup, Capsule & Liquid drops
AvailabilityOnly on prescription
Pregnancy categoryC
ATC ClassificationN02AX02 
Common brand namesInvodol, Larapam, Mabron, Maneo, Marol, Maxitram, Oldaram, Tilodol, Tradorec, Tramquel, Tramulief, Zamadol, Zeridame and Zydol

Key Facts of Tramadol Hydrochloride

Strong painkiller used only when normal painkillers does not provide significant relief.

Due to its opioid properties it causes most common side effects like headache and dizziness.

It is not advised to drive a vehicle or operate any vehicle after taking Tramadol.

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Make sure that you do not consume more dose of Tramadol than the prescribed dose.

It is super necessary to avoid alcohol while taking Tramadol as it may make you more prone to serious side effects.

Types of Tramadol Hydrochloride

Immediate release tablets – they are mainly used for rapid onset of action, usually contains 50 mg of Tramadol Hydrochloride.

Extended release tablets – this type of formulation is mainly used for the management of chronic pain for longer duration. it may contain 50mg, 75mg, 100mg, 150mg, 200mg, 300mg or 400mg of tramadol.

Liquid drops – those people who find difficult to swallow a pill can go with this type of preparation. these drops can contain 100mg of tramadol in 1ml of liquid.

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Injection – it is a rapid acting formulation, primarily used in the hospitals in emergency conditions.

Dissolve in the mouth tablet – this type of tablets gets easily dissolved in the mouth.

How Does Tramadol Works?

Tramadol works on the CNS by inhibiting reuptake of norepinephrine, serotonin and enhances serotonin release. Tramadol alters perception and response to pain by binding to mu-opiate receptors in the CNS.

Half-lifeSix hours
Time to reach peak plasma concentrationExtended Release: 12 hours, Immediate Release: 1.6 to 1.9 hours
StrengthExtended Release: 100 mg, 200 mg, 300 mg, Immediate Release: 50 mg
ExcretionExcreted mainly in urine

Precautions Of Tramadol Hydrochloride

Tramadol Hydrochloride is not suitable for some people. Take precautions if you have any of the following conditions.

  • Allergic to Tramadol or any other ingredient of the pill.
  • Kidney or Liver problems.
  • If you are suffering from emotional disturbance or depression.
  • If you have a history of epilepsy, seizure or head injury.
  • Addiction of alcohol or strong painkiller.
  • Pregnant or breastfeeding women’s should avoid this medication.

Side Effects of Tramadol Hydrochloride

Although, Tramadol Hydrochloride is a safe medication but in some patient, it can cause some side effects.

Most of the side effects occur during the initial treatment rather than maintenance doses of the drug.

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Common side effects

Nausea,

Dizziness,

Constipation,

Vomiting,

Somnolence,

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Headache.

Serious side effects

Serious side effects are very rare and may occur in a very small percentage of patient consuming tramadol.

Respiratory depression,

Hallucinations,

Confusion,

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Seizures,

Anaphylaxis.

If any side effects bother you and do not go away in a short time, you should immediately contact the doctor or medical health professional.

Drug Interaction of Tramadol Hydrochloride

Serotonin-norepinephrine reuptake Inhibitor – Subsequent consumption of Tramadol Increases the risk of convulsions or serotonin syndrome.

Bupropion, Mirtazapine, Tetrahydrocannabinol – Increases the risk of convulsions.

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Carbamazepine – Decreases serum concentrations of Tramadol Hydrochloride.

Other drugs which should be avoided:

  • Furazolidone
  • Iproniazid
  • Isocarboxazid
  • Linezolid
  • Methylene Blue
  • Moclobemide
  • Nalmefene
  • Naltrexone
  • Nialamide
  • Phenelzine
  • Procarbazine
  • Rasagiline
  • Safinamide
  • Samidorphan
  • Selegiline
  • Tranylcypromine

Safety of Tramadol Hydrochloride In Pregnancy

Tramadol is pregnancy category c drug and not completely safe to take while being pregnant.

Using Tramadol during pregnancy can cause neonatal withdrawal syndrome or birth defects in the newborn baby.

It is advised to inform your doctor right away if you think you are pregnant or if you plan to become pregnant while using this medicine.

Tramadol Safety In Breastfeeding

Usually, it is safe to breastfeed while taking tramadol medication. As it passes into breast milk in very small quantity but it’s unlikely to harm your baby.

However, Contact your doctor if you feel any notable changes or side effects in your baby.

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Common Questions Regarding Tramadol Hydrochloride

  1. What is tramadol hydrochloride?

    Tramadol is a narcotic analgesic drug, used in the management of chronic pain like postoperative pain & other long term pain disease.

  2. What are common side effects of tramadol hydrochloride?

    The most common side effects of tramadol are nausea, dizziness, constipation, vomiting, somnolence, and headache.

  3. What is the common dosage of tramadol 50 mg medication?

    The usual dosage is decided by your doctor depending on your condition and response to treatment. The usual dose is once a day and may vary according to your condition.

  4. How long should i consume tramadol medication?

    Do not consume tramadol for more than 10 days unless it is recommended by your doctor.

  5. What if i dont get relief after consuming tramadol?

    Talk to your doctor if you do not feel any relief after taking tramadol. ask your doctor for alternative drug.

  6. Is tramadol hydrochloride addicted in nature?

    Yes, Tramadol is narcotic analgesic and it can cause addiction if misused.

  7. Can i drink alcohol while taking tramadol?

    No, do not drink alcohol while taking tramadol as it may increase the risk of side effect.

  8. Can I drive the vehicle after taking tramadol hydrochloride?

    Do not drive a car or operate a heavy machinery if tramadol makes you sleepy during the daytime, gives you blurred vision or makes you feel dizzy, sleepy or unable to concentrate or make decisions. 

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