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Everything You Need to Know About Orange Round I 2 Pill

i7 pill

Orange Round Pill with I 2 marking impression is an antidepressant pill containing Amitriptyline Hydrochloride 25 mg as an active ingredient.

Amitriptyline Hydrochloride 25 mg (Orange Round I 2 Pill) is used in the treatment of Depression, Anxiety, Nocturnal enuresis, Prophylaxis of migraine and Neuropathic pain.

I 2 Orange Round Pill does not comes under Controlled Substances Act (CSA) and hence you can get it on normal prescription without any restriction like narcotic substances.

Pill NameI 2 Orange Round Pill
Pregnancy CategoryPregnancy Category C
About I 2 Pill
  • Always take I 2 Orange Round Pill at the bed time as it may make you feel very sleepy or dizzy.
  • I 2 Orange Round Pill may cause some withdrawal symptoms if discontinued suddenly. Talk to your doctor about discontinuation plan.
  • This pill may be prescribed for a longer duration, should be used according to doctor’s recommendation.
  • Common dosage of I 2 Orange Round Pill is said to be single dose in the evening.

I 2 Pill Uses

I 2 Pill is clinically proven to show significant improvement in the treatment of Depression, Nocturnal enuresis, Prophylaxis of migraine & Neuropathic pain.



It is an mental health condition characterized by the significant decrease in mood, loss of interest in doing daily interest & causing significant defacement in daily life.

I 2 Pill (Amitriptyline) is FDA approved medication to treat depression in adults.

According to this study, Amitriptyline (I 2 Pill) is an significantly effective drug in the treatment of Depression. However, the study also shows that Amitriptyline is also associated with common side effects like Headache & Diziness which will be discussed in details in the side effect section. (Source)

2.Nocturnal enuresis

Nocturnal enuresis
Nocturnal enuresis

It is also known as nighttime incontinence or nocturnal enuresis, It is a condition characterized by the urination while asleep after the age (5 Years) at which staying dry at night can be reasonably expected.

In this study conducted on 50 enuretic childrens aged between 5-15, It was found that Amitriptyline (I 2 Round Pill) in doses of 25 mg decreased frequency of nights with enuresis. (Source)

Another comparative study shows superiority of Amitriptyline over Desmopressin. Also, 25 mg of Amitriptyline has lesser side effects compared to drug Desmopressin. (Source)

3.Neuropathic Pain

Neuropathic Pain
Neuropathic Pain

Neuropathic Pain is a result of damaged nervous system, a shooting, stabbing or burning sensation are common types of neuropathic pain. they can be temporary or sometimes last longer than usual duration.

Amitriptyline (I 2 Pill) is recommended as a first line treatment on Neuropathic pain. It does significantly reduces the neuropathic pain by reducing body’s response to the pain. (Source)

This recent study conclude that Amitriptyline (I 2 Pill) relieves pain in diabetic neuropathy and this effect is independent of mood elevation. (Source)

How does I 2 Orange Round Pill work?

I2 (Amitriptyline Hydrochloride 25 mg) Pill is a popular and clinically proven antidepressant. It works by inhibiting the neuronal reuptake of serotonin (5-HT) and/or norepinephrine by the presynaptic neuronal membrane, hence increasing the synaptic concentration in the CNS.

It also possesses affinity for muscarinic and histamine (H1) receptors to varying degrees.

Adverse Effects / Side Effects

Like any other medications, I 2 Orange Pill also cause some mild to moderate side effects.

The most commonly encountered side effects of I 2 Orange Pill include:

  • Weight gain,
  • Constipation,
  • Xerostomia,
  • Dizziness,
  • Headache,
  • Somnolence,

Severe Side Effects

  • CNS depression,
  • Bone fractures,
  • Bone marrow suppression,
  • Heart block,
  • Arrythmias,
  • Tachycardia,
  • Palpitation,

Do not get frightened by the severe side effects, They are very rare and most of the users don’t even get it.

Common side effects usually goes away on its own without any special treatment.

Contraindications & Precautions

Contraindications and Precautions should be considered as most critical aspects while taking a drug or a pill. The following are significant considerations for I 2 Pill:

  • Allergic Reactions: Patients with past history of allergic reactions to any of the ingredient of I 2 Pill should avoid this pill completely.
  • I 2 Pill should not be used if there is a history of Heart diseases like Arrhythmias, recent Myocardial infarction, or Heart failure. (As per the FDA product labeling. Amitriptyline toxicity may cause acute myocardial infarction)
  • Disease Conditions – Patients with Angle-closure glaucoma, Urinary retention, Seizures should take this pill with precautions.
  • Kidney & Liver Disease – Lower doses are advised in renal and hepatic impairment.
  • Discontinue I 2 Pill before undergoing any surgical procedure as it may interact with anesthetic agents and cause severe complications in surgical procedure.
  • Alcohol – Consumption of any alcoholic beverage should be avoided while taking I 2 Pill as it may cause severe side efffects.

Drug Interactions of I 2 Pill

Drug interaction can change the way i2 pill works and may produce some undesired adverse interactions.

It is advised to avoid any other medication along with i2 pill which are listed below.

  • Astemizole,
  • Cisapride,
  • Disopyramide,
  • Ibutilide,
  • Indapamide,
  • Pentamidine,
  • Pimozide,
  • Procainamide,
  • Quinidine,
  • Sotalol,
  • Terfenadine,

Adrenaline, Phenylephrine – May potentiate CV effects of sympathomimetic agents.

Betanidine, Clonidine – May reduce antihypertensive effects of adrenergic neuron blockers.

Quinidine, Amiodarone – May increase ventricular arrythmias with antiarrhythmics.

Fluconazole – May increase serum concentrations.

Cimetidine – Increased plasma concentration.

Storage of I2 Pill

  • Store i2 Pill in a cool and dry place and protected from moisture.
  • Keep it out of the reach of children.

In case of expired i2 pill, Talk to your pharmacist about recycling of a product or safe disposal of pill.

Frequently Asked Questions

  1. What is Orange Round I2 Pill?

    Orange Round Pill with I 2 marking impression is an antidepressant pill containing Amitriptyline Hydrochloride 25 mg as an active ingredient.

  2. Why Orange Round i2 Pill is used?

    Amitriptyline Hydrochloride 25 mg (Orange Round I 2 Pill) is used in the treatment of Depression, Anxiety, Nocturnal enuresis, Prophylaxis of migraine and Neuropathic pain.

  3. What if i miss any dose of i2 pill?

    Take it as soon as you remember it. However if it is almost time for next dose then you should skip the missed dose and continue with upcoming dose.

  4. Can pregnant women take i2 pill?

    No, i2 pill is an pregnancy category c which can not be taken by the pregnant womens.

  5. Can i take i2 Pill for more than 10 days?

    No, You should not take I2 Pill for more than 10 days unless it is recommended by the doctor.

  6. Is it safe to drive a vehicle after taking i2 pill?

    Do not drive a vehicle, If you are feeling dizzy or sleepy after taking i2 pill.

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