Trilostane was taken off the market in April 1994 due to its potential side effects and lack of effectiveness. Trilostane is a medication used to treat Cushing’s syndrome, a condition caused by an overproduction of cortisol in the body.
However, studies showed that Trilostane was not consistently effective in treating the symptoms of Cushing’s syndrome and had a high rate of adverse effects.
These side effects included gastrointestinal problems, skin reactions, and changes in liver function. Additionally, Trilostane poses a risk for adrenal insufficiency, a condition where the adrenal glands do not produce enough hormones.
Due to these concerns, the decision was made to withdraw Trilostane from the market in the United States.
It is important to note that this decision was specific to the U.S. market and may not reflect its availability or use in other countries.