The 54 27 pill is an over-the-counter (OTC) pain reliever and fever reducer containing Acetaminophen 500 mg (Extra Strength). Distributed by generic healthcare suppliers such as Major Pharmaceuticals, Rugby Laboratories, and Cardinal Health, this tablet is the generic equivalent of brand-name Tylenol Extra Strength.
Acetaminophen belongs to the class of medications known as analgesics (pain relievers) and antipyretics (fever reducers).
Pill Identification
Attribute Details
- Active Ingredient – Acetaminophen (500 mg)
- Imprint Code – 54 27
- Color – White
- Shape – Round
- Score Line – Scored (2 pieces)
- Size – 12 mm
- Brand Equivalent – Generic Extra Strength Tylenol
- Drug Class – Non-opioid Analgesic / Antipyretic
- Imprint Note: Ensure the tablet is explicitly marked 54 27 on one face. Other imprints with additional digits (e.g., 54 271 which is Clarithromycin 250 mg) represent entirely different medications.
Indications & Dosage
Approved Uses
- Fever Reduction: Temporary lowering of elevated body temperature caused by viral or bacterial infections.
- Mild to Moderate Pain Relief: Temporary alleviation of minor aches and pains associated with:
- Headaches and migraines
- Muscle aches and backaches
- Toothaches
- Arthritis and joint discomfort
- Premenstrual and menstrual cramps
- Common cold symptoms
Standard Adult & Adolescent Dosage Guidelines
- Adults and Children 12 Years and Older: Take 2 tablets (1,000 mg) every 6 hours while symptoms persist.
- Maximum Daily Dose: Do not exceed 4,000 mg (8 tablets) within a 24-hour period.
- Children under 12 Years: Consult a physician for weight-appropriate pediatric liquid or chewable formulations.
Side Effects
Acetaminophen is exceptionally safe when taken strictly as directed, but side effects can occur:
Rare / Mild Side Effects
- Mild gastrointestinal upset or nausea
- Headache or fatigue
- Mild insomnia
Serious Adverse Effects (Immediate Medical Attention Required)
- Allergic Reactions: Hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
- Severe Skin Reactions: In rare cases, acetaminophen can trigger severe skin reactions such as Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN), causing skin reddening, blisters, and peeling rash. Discontinue use immediately if a new rash develops.
Major Warnings & Precautions
Severe Liver Warning (Hepatotoxicity)
Acetaminophen overdose is the leading cause of acute liver failure. Severe, life-threatening liver damage may occur if you:
- Take more than 4,000 mg of acetaminophen in 24 hours.
- Take it concurrently with other prescription or nonprescription medications containing acetaminophen (e.g., combination cough/cold syrups, Vicodin, Percocet).
- Consume 3 or more alcoholic drinks every day while using this medication.
Pre-existing Conditions & Interactions
- Liver Disease: Consult a doctor prior to use if you have cirrhosis, hepatitis, or impaired liver function.
- Warfarin (Blood Thinners): Patients taking chronic warfarin therapy should consult a physician before using acetaminophen regularly, as high doses can increase anti-coagulation levels and elevation of INR (bleeding risk).
Usage Limits
- Pain: Do not use for longer than 10 days unless directed by a doctor.
- Fever: Do not use for longer than 3 days for fever unless directed by a doctor.